European Journal of Molecular & Clinical Medicine

Abstract

Emergence agitation (EA) presents clinically as disorientation, restlessness, excitation, inconsolability, unnecessary movement, incoherence and thrashing during the initial recovery from general anesthesia. Beneficial effects of dexmedetomidine (DEX) against emergence agitation (EA) in adults remain controversial.
Aim and Objective : To compare the effects  of Dexmedetomidine and Fentanyl on emergence delirium and quality of recovery from general anaesthesia after laparoscopic surgeries. Material and Method : This was the Hospital based prospective, randomized double blind clinical trial. conducted on patients receiving IV dexmedetomidine versus IV Fentanyl among Patients undergoing laparoscopic surgeries under general anaesthesia. A Total 100 patients, allocated to two groups of 50 each (n=50), after following inclusion and exclusion criteria and getting informed consent form patients. p-value<0.01 was statistically significant.
Results: Mean difference between the group for age,  Time duration at PACU, Duration of Surgery was assessed by using t-test, and difference in the proportion between the groups were assessed by using chi-square test for proportions. p-value less than 0.05 was consider statistically significant at 5% level of significance.time taken for verbal response was statically significant between the groups and this time was more  in group D compared to Group F, also PACU stay was statistically significant and more time was taken in group D. Riker Sedation-Agitation Scale between the groups and we had more patients observed calm and cooperative in group D but in group F we have observed patients with agitated to dangerous agitation. Conclusion: Premedication with dexmedetomidine 1mcg/kg intravenously provides better quality and haemodynamic of extubation and reduces emergence agiation compared to fentanyl 1mcg/kg in adults undergoing laparoscopic surgeries.