The Use of Bone Grafts for Local Antibiotic Delivery in Bone Reconstruction Surgery: Recent Advances
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 4, Pages 466-481
AbstractOne of the main problems in bone and joint surgery is still infection related to bone implants. In both the treatment and prevention of these infections, antibiotic-impregnated bone transplants appear to hold promise. Nonetheless, this field of research is characterized by a wide range of methodologies. An overview of the published literature is provided in this essay.
Method: The Medline database was searched, and articles were chosen based on pre-established exclusion criteria.
Results: The synthesis contained 45 papers. Studies were conducted on issues such as the type of bone graft, graft operations, elution profile, bacterial inhibition, oestotoxicity, incorporation, unique impregnation techniques, clinical use, and storage. From a therapeutic standpoint, large initial concentrations seem suitable for eliminating biofilm. It appears possible to treat an infection caused by a bone implant in a single step. When employing antibiotic-impregnated bone grafts, the literature suggests a reduction in postoperative infections as a preventative measure.
Conclusion: Both therapeutically and preventatively, local antibiotic treatment can be applied to bone grafts.
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