Prevalence of C/T Allele of Il1b Gene Along with its Relationship in Polymorphism (-511C/T) with Vitiligo
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 3, Pages 1628-1632
AbstractVitiligo is a condition where white patches appear on the skin due to lack of melanin pigment. It can appear on any part of the body, but most commonly affected areas are face, neck, and hand. It can cause significant psychological and social distress in patient suffering from it. Methodology- The study was conducted at Central Research Laboratory and Department of Skin and VD, Sri Aurobindo Medical College and Post Graduate Institute, Indore, from Oct 2014 to Jun 2016. 84 known patients of vitiligo were recruited for the study. Patients were diagnosed to have vitiligo based on history, duration, progression of disease presence of depigmented patch and appearance of chalky white on wood’s lamp examination. DNA was extracted from EDTA blood using Himedia HiPurA kit. The IL1B -511C/T SNP was genotyped using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) method. Results- C allele was observed in 53% of cases and 50.6% of controls whereas T allele was present in 47 % of cases and 53% of controls. No association of T allele with the presence of vitiligo was seen in present study (p = 0.910) Conclusion- No significant association of IL1B -511C/T (rs 16944) polymorphism at genotype level and allele level was seen with the vitiligo in this study. None of the model was found associated with vitiligo.
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