Association of 511 C/T Polymorphism of Interlukin 18 Gene Along with Prevalence of C/T Allele of Il1b Gene in Case and Controls of Vitiligo
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 3, Pages 1633-1640
Abstract
Vitiligo is characterized by a disappearance of epidermal and/or follicular melanocytes which result in pale white patches on skin. It is an autoimmune disease and can develop at any age and in any gender. People affected by vitiligo can experience low self-esteem and concern about their appearance, leading to disturbed mental state and thereby affecting the quality of life. Methodology- The study was conducted at Sri Aurobindo Medical College and Post Graduate Institute, Indore, Central Research Laboratory and Department of Skin and VD, from Oct 2014 to April 2016. 84 patients who were known case of vitiligo were enrolled for the study. Written informed written consent was taken from all the patients. Detailed clinical examination was done on all patients to rule out other systemic disorders. 5ml of blood samples were collected in plain and EDTA tube from peripheral veins under aseptic precautions. Serum was separated by centrifugation of plain tube at 2000rpm.DNA isolation process was done.Results- The frequency of CC, CT and TT genotype of IL1b gene in our study was 27.4%, 48.8% and 23.8% cases and that were in controls were 28.8%, 43.8% and 27.4% respectively. Conclusion- No significant association of Il1b -511C/T polymorphism at genotype level was seen with the vitiligo
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