European Journal of Molecular & Clinical Medicine

Abstract

Diabetes has emerged as one of the most serious and common chronic diseases of our times, causing life threatening, disabling and costly complications, and reducing life expectancy. Type 2 diabetes (T2D) is a multifactorial disease affecting mostly adults older than 40 years. The aim of the study was to examine GST gene polymorphism influence on the risk of T2D, especially in young adults. Research design and methods: 50 diabetic patients and 50 healthy controls participated in this study.  GST gene polymorphism has been analyzed using TaqMan real-time quantitative PCR. Results The distribution of examined polymorphisms was similar in patient group and control group. Statistically no significant differences were demonstrated for GSTT1/M1 genotypes. We found a significant association with GSTT1 gene with lipid profile and blood pressure.  Conclusion: The results of our study suggest that GST polymorphism may be one of the risk factors for developing T2D Dyslipidemia and patients are at the high risk of coronary artery disease