Estimation of Oct 4 in Malignant Oral Diseases: An Original Research
European Journal of Molecular & Clinical Medicine,
2023, Volume 10, Issue 4, Pages 1302-1306
AbstractEvaluation of OCT 4 expression in oral squamous cell carcinoma is the goal.
Materials and methods: The study contained 30 samples of archival tissue blocks, which were then divided into 10 each for the Well-differentiated & Moderately differentiated squamous cell carcinoma in the Cases (Oral squamous cell cancer) groups and 10 blocks for the control normal mucosa. Anti-Oct-4 antibody was used for immunohistochemical staining on the sections of Group I and Group II. The cells were counted, and the data were compared for significance with a p-value of 0.05 being considered significant.
Results: When the mean number of positive cells is compared between the control and study groups, statistical significance is seen on the correlation of OCT 4 expressions. When the average number of positive cells in normal mucosa and moderately differentiated Squamous cell carcinoma are compared, a strong statistical significance is seen on the association of OCT 4 expressions.
Conclusion: It appears that OCT 4 is involved in determining the prognosis of oral squamous cell carcinoma patients since its quantitative expression rose from normal mucosa to the well-differentiated variation of the disease, and then to the moderately differentiated variant
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