Abstract

Background: Cervical cancer is a preventable disease because it has a premalignant stage which may last up to 10-20 years before its progression to invasive carcinoma. The potential role of ROS in DNA damage as well as the nutritional etiology of cervical neoplasia (which include low dietary intake of vitamin C, carotenoids, vitamin E, and folate) has been suggested. Objectives: The objective of this study is to measure the oxidant status. To estimate and compare serum levels of MDA (malondialdehyde) in postmenopausal cervical cancer patients and healthy age matched control. Methodology: This case control study consist of 90 patients of cervical cancer along with 60 healthy subjects of précised matched age within the institution. blood samples was collected from all participants and were analysed for oxidant MDA (malondialdehyde) .Results obtained were analyzed statistically to see the significance of differences. Results: The Mean concentration of S.MDA (nmol/L) in case group was 5.77 ±2.40 while that of control group 2.03±0.70 and the difference among them found to be highly significant. The mean age of cervical cancer group(case) is 51.26 ±5.43 yr while that of control group is 55.60±4.50 year. According to demographic data .Smoking history present in 16% and 11% in case and control group respectively.History of alcohol present in 9.9% and 4.2% in case and control group respectively.Among total 90 patients of cervical cancer 86(95.55%) females were married. Conclusion: In conclusion, this study has shown that the patients with cervical cancer have high lipid peroxidation (MDA), which is a marker of oxidative stress; and this worsened as the disease progressed. There is a need for antioxidant supplementation in these patients to reduce oxidative stress.