Document Type : Research Article
Anemia is a worldwide public health issue that affects both developing and industrialized nations. The present study was conducted to find association of iron deficiency anemia with Hba1c levels in non-diabetics and effect of iron therapy on Hba1c levels.
Materials & Methods: 90 patients with iron deficiency anemia of both genders underwent investigations like HbA1c, Serum Ferritin, Serum Iron, Total Iron Binding Capacity (TIBC), Haemoglobin, Peripheral Smear Examination, Mean Corpuscular Haemoglobin (MCH), Mean Corpuscular Volume (MCV), Mean Corpuscular Haemoglobin Concentration (MCHC), Blood Urea and Serum Creatinine. For the determination of serum iron and TIBC, ferrozine/ MgCO3 method was used. Serum ferritin was measured using chemiluminescence based method. HbA1c was calculated using sandwich ELISA method. Haemogram was calculated using autoanalyzer PCi20+.
Results: Majority of patients belonged to age group 61-70 year 28 (37.3%) followed by 51-60 years 23 (30.7%), 41-50 years 10 (13.3%), <=30 years 8 (10.7%) and 31-40 years 6 (8%).51 (68%) of the patients were female while 24 (32%) patients were male. Majority of patients had moderate anemia 49 (65.3%), followed by mild anemia seen in 16 (21.3%) and severe anemia was seen in 10 (13.3%) patients. On comparing the data at baseline and 3 months we observed that mean haemoglobin level at baseline (9.56 ± 1.36 gm/dl) was significantly less than at 3 months (11.12 ± 1.36 gm/dl) (p<0.001). Serum iron at baseline was 20 ± 5.49 mcg/dl while at 3 months it was 63.66 ± 31.76 mcg/dl. Serum iron increased significantly at 3 months (p<0.001). TIBC was 390.12 ± 19.09 mcg/dl at baseline while at 3 months it was 347 ± 30.18. TIBC (mcg/dl) was significantly less at 3 months (p<0.001). Serum ferritin also increased significantly at 3 months with 50.28 ± 37.68 ng/ml as compared to 8.92 ± 3.37 at baseline(p<0.001). HbA1c decreased significantly at 3 months. At baseline it was 5.54 ± 0.33% while it decreased to 5.16 ± 0.2% at 3 months (p<0.001).At baseline HbA1c had negative excellent correlation with Hb (-.868) while after iron supplementation there was decrease in HbA1c levels and increase in Hb levels. HbA1c and haemoglobin at 3 months showed negative moderate correlation with pearson’s coefficient value being -0.55, this association was statistically significant (p<0.001). This signifies that as the value of Hb increases there is a moderate decrease in HbA1c.
Conclusion: There was a significant correlation between IDA and elevated HbA1C level in non- diabetic population. HbA1C increases with severity of anaemia and vice versa