Synthesis of some New 4,6-dichloro-2-aminobenzothiazole compensators with expected biological
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 2, Pages 1595-1606
Abstract
was prepared from the reaction of compensated aniline with potassium thiocyanate in the presence of bromine. UnsaturatedAlpha-Beta (E2-6) compounds were obtained from the reaction of aromatizing aldehydes with para –hydroxyacetophenone in a
basal medium. The interaction of alpha-beta - unsaturated compounds with 4,6-dichloro-2-aminobenzothiazole gives
compounds (E7-11) 4-(1-(4,6-dichlorobenzothiazole-2-El amino) - 3-aryl) phenol. The bioavailability of compounds prepared
on two types of Gram-negative and Gram-positive bacteria was tested using a lower inhibitory concentration and compared
with standard antibiotics. The prepared compositions were validated using physical and spectral methods using FT-IR,H1-
NMR,C13NMR technology
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