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Cytogenetic and immunological alterations of recurrent bladder cancer

    Authors

    • Shukhrat Ziyadullaev 1
    • Obid Elmamatov 2
    • Nodir Raximov 2
    • Farkhod Raufov 2

    1 Samarkand Medical Institute, Samarkand, Uzbekistan

    2 Republican Specialized Medical Center for Oncology and Radiology, Tashkent, Uzbekistan

,

Document Type : Research Article

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Abstract

Abstract: In this review, we discussed genetic and immunological changes of bladder
cancer along with relapse of this disease; however, it should be noted that in most cases,
multiple genetic and immunological changes occur simultaneously or mutually dependent
on each other. Many genetic mutations disrupt the function of genes involved in
regulation, and conversely, chromosomal aberrations lead to changes in transcription.
Pathogenesis and transition of normal urothelium of bladder into cancer are multifactorial
processes. Chronic inflammation causes the initiation and progression of the main
pathophysiology of invasive and metastatic cancer. A dichotomy is observed in the role of
immune cells in bladder cancer. Although the immune response protects the bladder by
suppressing tumor growth, certain immune cells including neutrophils, macrophages, and
T-lymphocytes contribute the development and progression of the tumor.

Keywords

  • bladder cancer
  • Relapse
  • immune cells
  • cytogenetics
  • chromosomal aberrations
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 2
November 2020
Page 1877-1883
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  • Article View: 238
  • PDF Download: 557

APA

Ziyadullaev, S., Elmamatov, O., Raximov, N., & Raufov, F. (2020). Cytogenetic and immunological alterations of recurrent bladder cancer. European Journal of Molecular & Clinical Medicine, 7(2), 1877-1883.

MLA

Shukhrat Ziyadullaev; Obid Elmamatov; Nodir Raximov; Farkhod Raufov. "Cytogenetic and immunological alterations of recurrent bladder cancer". European Journal of Molecular & Clinical Medicine, 7, 2, 2020, 1877-1883.

HARVARD

Ziyadullaev, S., Elmamatov, O., Raximov, N., Raufov, F. (2020). 'Cytogenetic and immunological alterations of recurrent bladder cancer', European Journal of Molecular & Clinical Medicine, 7(2), pp. 1877-1883.

VANCOUVER

Ziyadullaev, S., Elmamatov, O., Raximov, N., Raufov, F. Cytogenetic and immunological alterations of recurrent bladder cancer. European Journal of Molecular & Clinical Medicine, 2020; 7(2): 1877-1883.

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