• Register
  • Login

European Journal of Molecular & Clinical Medicine

  • Home
  • Browse
    • Current Issue
    • By Issue
    • By Subject
    • Keyword Index
    • Author Index
    • Indexing Databases XML
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
Advanced Search

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 7, Issue 2
  3. Authors

Online ISSN: 2515-8260

Volume7, Issue2

Fetal haemoglobin: A novel prognostic determinant in sickle cell anaemia

    Dr. Obaid Noman Dr. Arvind Bhake Dr. Shweta Bahadure Dr. Nihar Gupta

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 2, Pages 2003-2008

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Background-Acknowledgement of instrumental action of fetal hemoglobin(HbF)
in improving the clinical condition of sickle cell disease (SCD) patients, began around 7
decades back, by Janet Watson who found that infants with SCD had lesser symptoms and
their deoxygenated RBCs did not sickle or deform as aggressively as their mothers having
sickle cell trait. She proposed high HbF levels in infant blood as compared to mothers for
the observations of her study. Reduced incidence of crisis like vaso-occlusive, haemolytic,
aplastic, megaloblastic, infectious and others have been found with higher HbF levels.
With this backdrop the present study is being undertaken to know the reciprocity between
HbF levels and the state of crisis in sickle cell. The study is expected to fill the missing link
between “Why a few patients with HbS with haemoglobin pattern of SS suffer less from
crisis than that of others with a similar haemoglobin pattern of SS”
Objectives:
• To know HbF levels in pateints with SCD with Hb (SS) pattern
• To draw the comparisons between HbF levels in SCD with Hb(SS) pattern in
subjects 1. With sickle cell crisis and 2. Without sickle cell crisis
• To find out cut-off level of Hb F at its protective effect against the crisis in SCD
Methodology
• Study design - Observational and analytical study
• Sample size - Total of 30 Patients of sickle cell Disease (Hb SS)
• Study duration - 1 year
Expected Results: Incidence of Crisis in HbSS patients are expected to have a inverse
relationship with HbF levels. A cut-off level of HbF above which episodes of crisis are
lower can be expected to be found. Conclusion: Conclusions will be drawn from results
obtained and an attempt to establish a cut-off HbF value which renders a protective action
against crisis in SCD will be made.
Keywords:
    Keywords: HbSS SCD Foetal Haemoglobin Sickle Cell Disease crisis
  • PDF (294 K)
  • XML
(2020). Fetal haemoglobin: A novel prognostic determinant in sickle cell anaemia. European Journal of Molecular & Clinical Medicine, 7(2), 2003-2008.
Dr. Obaid Noman; Dr. Arvind Bhake; Dr. Shweta Bahadure; Dr. Nihar Gupta. "Fetal haemoglobin: A novel prognostic determinant in sickle cell anaemia". European Journal of Molecular & Clinical Medicine, 7, 2, 2020, 2003-2008.
(2020). 'Fetal haemoglobin: A novel prognostic determinant in sickle cell anaemia', European Journal of Molecular & Clinical Medicine, 7(2), pp. 2003-2008.
Fetal haemoglobin: A novel prognostic determinant in sickle cell anaemia. European Journal of Molecular & Clinical Medicine, 2020; 7(2): 2003-2008.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 214
  • PDF Download: 297
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
Journal Information

Publisher:

Email:  editor.ejmcm21@gmail.com

  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus