Abstract

Abstract: The task of the present paper is to develop scientific bases and technological
solutions for creating a combined pharmaceutical composition for normalization of intestinal
system function. The assigned task is solved by a combination of energy sorbent of
montmorillonite clay with a mixture of probiotic - Lastobacillus plantarum mal and prebiotic
inulin. The creation of such a composition is the most effective for normalization of intestinal
system function since prebiotic products create a favorable and complete nutrient environment
for maintenance and growth of the useful microbial culture of probiotics that were in
annibiosis (inactive state), and the enterosorbent of montmorillonite clay provides "adsorption
activity" for adsorption of toxic substances. The essence of the technology for obtaining a
combined pharmaceutical composition for the normalization of intestinal system function,
containing prebiotic and probiotic, as well as enterosorbent - montmorillonitic clay, in which
from dry inulin - prebiotic prepare aqueous solution, then it is sterilized by autoclaving, added
probiotic culture Lastobacillus plantarum mal, which is restored from the dried state by three
times crossing into the MRS - broth, At the same time, Lastobacillus plantarum mal is
centrifuged, cells are separated from the cultural liquid and thoroughly mixed before
lyophilisation of the substance. The suspension is mixed with a protective medium consisting
of milk, sugar and gelatine, the resulting mixture is also subjected to lyophilic drying, the dry
amorphous biomass is added to autoclaved montmorrillionite clay and the final product is
light brown with a pleasant sour-milk smell. This product serves as a sachet filling station -
sachets with additives.