European Journal of Molecular & Clinical Medicine

Abstract

Abstract. In order to determine the role of polymorphic variants of the tumor necrosis
factor α gene (TNFα -308G> A) in the development and course of chronic respiratory
diseases, an analysis was made of the frequency of alleles and genotypes in patients with
bronchial asthma and chronic bronchitis and healthy individuals of the Uzbek population.
An analysis of the frequency distribution of genotypes and alleles of the studied gene
showed that risk allele A and genotype A/A and A/G are markers of an increased risk of
developing a disease of the bronchopulmonary system both in the group of patients with
bronchial asthma and in children with chronic bronchitis.