European Journal of Molecular & Clinical Medicine

Abstract

Lichen planus is an autoimmune disorder that primarily affects the body's skin and
multiple mucous membranes. In multicellular species, protein 53 and syndecan-1protein
play an significant role since they control the cell cycle and thus play a major role in
tumor suppression and cancer prevention. The p53 gene was therefore identified as a
"genome protector," referring to its role in preserving the integrity of genetic
information by preventing gene mutations. The purpose of this analysis was to study the
association between certain immune markers in lichen planus patients.
The aim of this study : Study correlation between some immune marker in patients with
lichen planus
Methods 'Thirty formalin-fixed , paraffin-embedded tissue pieces, diagnosed as Oral
Lichen planus(OLP), were included in the sample of this report.
Results: Evaluation of P53 Immunohistochemistry and Evaluation of syndecan-
1protein Immunohistochemistry Conclusion: the marker p53 expression is high in the
patient with Lichen Planus while the second studed marker syndecan-1 protein is less
than marker p53