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  2. The Use Of Sonication Method For Reducing Size Of Liposomes In Papaya Leaf Extract (Carica Papaya Linn) Preparations As A Candidate In Treatment Of Cervical Cancer

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The Use Of Sonication Method For Reducing Size Of Liposomes In Papaya Leaf Extract (Carica Papaya Linn) Preparations As A Candidate In Treatment Of Cervical Cancer

    Authors

    • Yuly Peristiowati 1
    • Sandu Siyoto 2
    • Koesnadi . 2
    • Arina Chusnatayaini 3
    • Hariyono . 4

    1 Department of Nursing, Institute of Health Science Strada Indonesia Kediri, East Java, Indonesia

    2 Department of Publich Health, Institute of Health Science Strada Indonesia Kediri, East Java, Indonesia

    3 Department of Midwifery, Institute of Health Science Strada Indonesia Kediri, East Java, Indonesia

    4 Ministry of Environment in Kediri City, East Java, Indonesia

,

Document Type : Research Article

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Abstract

Liposomes are vesicle-shaped particles whose walls are composed of lipid molecules ( the main constituent is a double layer phospholipid which wraps the liquid compartment inside. Liposomes can be made from natural ingredients in the form of natural phospholipid derivatives mixed with fat chains (eg phosphatidylcholine) by dispersing. Liposomes from papaya leaf extract (Carica Papaya Linn) are made with the aim of increasing the effectiveness of the drug and biocompatible work, as well as protecting healthy tissue from the toxic effects of the drug. The process of making liposom papaya leaf extract using the sonication method by mixing soybean lecithin with papaya leaf extract. Then do the heating and sonication. This method is done to reduce particle size. The aim of this study was to produce an extract of liposomes from papaya leaf phospholipid formulations using a combination of heating and sonication. The method to produce liposomes with a size of <150 nm using a combination of heating 40○C for 40 minutes and stirring using ultraturrax at a speed of 15,000 rpm for 30 minutes, then stirring with a sonicator for 30 minutes. The results showed the liposome nano papaya leaf extract formulation from soybean lecithin by the PSA (Particle Size Analyzertype 1090 / Cilas) method. The liposome product was in the form of liquid, light green and milk white and odorless. Particle size distribution is obtained in the range of 0.04 μm - 500.00 μm / 100 Classes and an average pH of 5.45.

Keywords

  • cervical cancer
  • Liposomes
  • Papaya Leaf Extract
  • sonication
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 2
November 2020
Page 4703-4709
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  • Article View: 276
  • PDF Download: 270

APA

Peristiowati, Y., Siyoto, S., ., K., Chusnatayaini, A., & ., H. (2020). The Use Of Sonication Method For Reducing Size Of Liposomes In Papaya Leaf Extract (Carica Papaya Linn) Preparations As A Candidate In Treatment Of Cervical Cancer. European Journal of Molecular & Clinical Medicine, 7(2), 4703-4709.

MLA

Yuly Peristiowati; Sandu Siyoto; Koesnadi .; Arina Chusnatayaini; Hariyono .. "The Use Of Sonication Method For Reducing Size Of Liposomes In Papaya Leaf Extract (Carica Papaya Linn) Preparations As A Candidate In Treatment Of Cervical Cancer". European Journal of Molecular & Clinical Medicine, 7, 2, 2020, 4703-4709.

HARVARD

Peristiowati, Y., Siyoto, S., ., K., Chusnatayaini, A., ., H. (2020). 'The Use Of Sonication Method For Reducing Size Of Liposomes In Papaya Leaf Extract (Carica Papaya Linn) Preparations As A Candidate In Treatment Of Cervical Cancer', European Journal of Molecular & Clinical Medicine, 7(2), pp. 4703-4709.

VANCOUVER

Peristiowati, Y., Siyoto, S., ., K., Chusnatayaini, A., ., H. The Use Of Sonication Method For Reducing Size Of Liposomes In Papaya Leaf Extract (Carica Papaya Linn) Preparations As A Candidate In Treatment Of Cervical Cancer. European Journal of Molecular & Clinical Medicine, 2020; 7(2): 4703-4709.

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