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  2. Volume 7, Issue 1
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Online ISSN: 2515-8260

Volume7, Issue1

Computer Analysis of Local Field Potentials of MER Data with STN Deep Brain Stimulation in Parkinson`s Disease

    Anji Reddy Dabbeta Narsimha G Venkateshwarla Rama Raju

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 1, Pages 2405-2414

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Abstract

The local field potentials, i.e., the electrical-potentials of the deep brain stimulations (DBS) and micro electrode signal recordings of STN-neurons adjoining and contiguous DBS leads can vivid to give pragmatic rejoinder or snap therapeutic-surgical STN-DBS. Nevertheless, predictable square (conservative) DBS lead-electrodes amid four cylindrical macro/electrodes (for macrostimulations) likely under-sample the spatial circulation of sinks and sources in a given area of the brain. This study gives the exploration of the power-spectral-density (PSD) and spatial-feature dimensions of LFP-activity in primate subthalamic-nuclei (STN/or s-nuclei) and globus pallidus internus (GPi) by means of unendingly 32embedded-channel directional DBS-array-electrodes. The waveforms of s-nuclei and GPi were acquired as of directional-DBS-micro electrode-arrays in the latent or quiescent state and in a reach-and-retrieval task in two-primates in adolescent, naïve and immature (raw) animal Parkinson conditions. The potentials of signal acquisitions recordings were evaluated amongst bipolar-pairs of micro electrodes using personage and agglomerative (bunched) electrode configurations, with the latter mimicking the cylindrical macro electrode (for macro stimulations) arrangements/specifications employed in the present - current clinical settings of field-potentials signal acquisition. Signal recordings from these DBS-electrodes shown that, β-oscillatory frequency fluctuations have spatial-finger-prints in s-nuclei and GPi, and that these fluctuations were muted when clustering the electrode contacts together to create cylindrical macro electrodes alike in parallel and in
Keywords:
    deep brain stimulation local field potentials micro electrodes micro electrode recording Parkinson's disease internal global pallidus subthalamic nucleus
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(2020). Computer Analysis of Local Field Potentials of MER Data with STN Deep Brain Stimulation in Parkinson`s Disease. European Journal of Molecular & Clinical Medicine, 7(1), 2405-2414.
Anji Reddy Dabbeta; Narsimha G; Venkateshwarla Rama Raju. "Computer Analysis of Local Field Potentials of MER Data with STN Deep Brain Stimulation in Parkinson`s Disease". European Journal of Molecular & Clinical Medicine, 7, 1, 2020, 2405-2414.
(2020). 'Computer Analysis of Local Field Potentials of MER Data with STN Deep Brain Stimulation in Parkinson`s Disease', European Journal of Molecular & Clinical Medicine, 7(1), pp. 2405-2414.
Computer Analysis of Local Field Potentials of MER Data with STN Deep Brain Stimulation in Parkinson`s Disease. European Journal of Molecular & Clinical Medicine, 2020; 7(1): 2405-2414.
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