European Journal of Molecular & Clinical Medicine

Abstract

The new mannich bases 1-(((5-chloro-2,4-dimethoxyphenyl)amino)methyl)indoline-2,3-dione (L1) and 3-(((5-chloro-2,4-dimethoxyphenyl)amino)methyl)pyrimidine-2,4(1H,3H)-dione (L2) have been synthesized by condensation of isaten or thymine with formaldehyde and 5-chloro-2,4-dimethoxyaniline . The ligands have been characterized by various physical and spectral techniques such as Micro elemental analysis and spectroscopic methods ultraviolet-visible, infrared and nuclear magnetic resonance.Reaction of mannich bases (L1,L2) with one equivalents of metal salts (CoCl2.6H2O,NiCl2.6H2O and HgCl2) afforded the presumably tetrahedral complexes [M(L)Cl2] ;L is L1 or L2 .Reaction of [M(L)Cl2] with tertiary phosphines ligands ; dppm , PPh3 in molar ratios 1:1(complex : dppm ligand) or 1:2 (complex : PPh3 ligand ) afforded mixed ligands complexes [M(L)(phosphine)]Cl2 and [M(L)(phosphine)nCl2], where is L is L1,L2, phosphine is dppm,PPh3 and n=1or2.The synthesized complexes were characterized by the above mentioned techniques as well as the conductivity and magnetic measurements.The obtained results showed that the complexes have tetrahedral or octahedral geometry. The antibacterial activities of the ligands and some of prepared complexes against two types of bacteria are also reported.