European Journal of Molecular & Clinical Medicine

Abstract

A series of 1,2,4-triazine derivatives [1-9] were synthesized by various analogous methods. In this investigation 5,6-diphenyl-1,2,4-triazine-3-thiol compound [1] was prepared by cyclization of benzil with thiosemicarbazide. Further 5-(prop-2-en-1-yl)-5H-[1,2,4] triazino [5,6-b]indole-3-thiol compound [3] was prepared by treating 1-(prop-2-en-1-yl)-1h-indole-2,3-dione compound [2] with thiosemicarbazide. Further a variety of compounds were prepared by hydrogen replacement of compound [1] and compound [3] by differently active halogen containing scaffolds. Compound [1] was reacted with 9-(2-bromoethyl)-9H-carbazole to produce 9-(2-(5,6-diphenyl-1,2,4-triazin-3-yl)thio)ethyl)9-H-carbazole compound [4].After that, the compound [1] was allowed to react with 2-chloro-N-(4-methylbenzene-1-sulfonyl)-N-(pyridine-2-yl) acetamide to synthesize 2-((5,6-diphenyl-1,2,4-triazin-3-yl)-N-(Pyridin-2-yl)-N-tosylacetamide compound [5].In addition to this ,5,6-diphenyl-3-(tritylthio)-1,2,4-triazine compound [6] was also prepared by condensation reaction between trityl chloride and compound [1]. Further, Compound [3] was reacted with 9-(2-bromoethyl)-9H-carbazole to produce 3-((2-(9H-Carbazol-9-yl)ethylthio)-5-allyl-5H-[1,2,4]triazino[5,6-b]triazino[5,6-b]indole compound [7].After that, the compound [3] was allowed to react with 2-chloro-N-(4-methylbenzene-1-sulfonyl)-N-(pyridine-2-yl) acetamide to synthesize 2-((5-allyl-5H-[1,2,4]triazino[5,6-b]infol-3-yl)thio)-N-(pyridine-2-yl)-N-tosylacetamide compound [8].In addition to this ,5-allyl-3-(tritylthio)-5H-[1,2,4]triazino compound [9] was also prepared by condensation reaction between trityl chloride and compound [3]. All the synthesized compounds were confirmed by spectral data (Table 1) and analytical data (Table 2).