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  2. Volume 7, Issue 3
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Online ISSN: 2515-8260

Volume7, Issue3

ERYTHROCYTE TRANSMEMBRANE FLUX AND MEMBRANE TRANSPORT ABNORMALITY IN PATHOGENESIS OF HYPERTENSION LEADING TO NEPHROLITHIASIS

    RENUGADEVI KARTHIKEYAN JULIUS AMALDAS PRAKASH DHARMALINGAM

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 1698-1705

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Abstract

The epidemiological relationship between nephrolithiasis and hypertension is well-known. Patients with hypertension are at increased risk for nephrolithiasis and those with nephrolithiasis are at risk for hypertension. An anomaly in RBC Oxalate transport and reduced activities of adenosine triphosphatases has been reported in patients with hypertension when compare to control subjects. This study presents an abnormal increase in transmembrane flux of oxalate in RBC of hypertensive subjects and it might be due to membrane degradation caused by oxalate-induced free radicals depleting erythrocyte thiol contents and impaired adenosine triphosphatases activity resulting in tissue injury and defective membrane transport. Thus relative risk of hypertension was significantly associated with increased oxalate flux rate and impaired adenosine triphosphatases activity in stone formers. This association is important when treating patients with nephrolithiasis since those with hypertension may require unique dietary and medical therapy.
Keywords:
    Nephrolithiasis Hypertension Transmembrane flux Adenosine triphosphatases erythrocytes
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(2020). ERYTHROCYTE TRANSMEMBRANE FLUX AND MEMBRANE TRANSPORT ABNORMALITY IN PATHOGENESIS OF HYPERTENSION LEADING TO NEPHROLITHIASIS. European Journal of Molecular & Clinical Medicine, 7(3), 1698-1705.
RENUGADEVI KARTHIKEYAN; JULIUS AMALDAS; PRAKASH DHARMALINGAM. "ERYTHROCYTE TRANSMEMBRANE FLUX AND MEMBRANE TRANSPORT ABNORMALITY IN PATHOGENESIS OF HYPERTENSION LEADING TO NEPHROLITHIASIS". European Journal of Molecular & Clinical Medicine, 7, 3, 2020, 1698-1705.
(2020). 'ERYTHROCYTE TRANSMEMBRANE FLUX AND MEMBRANE TRANSPORT ABNORMALITY IN PATHOGENESIS OF HYPERTENSION LEADING TO NEPHROLITHIASIS', European Journal of Molecular & Clinical Medicine, 7(3), pp. 1698-1705.
ERYTHROCYTE TRANSMEMBRANE FLUX AND MEMBRANE TRANSPORT ABNORMALITY IN PATHOGENESIS OF HYPERTENSION LEADING TO NEPHROLITHIASIS. European Journal of Molecular & Clinical Medicine, 2020; 7(3): 1698-1705.
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