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  2. Volume 7, Issue 9
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Online ISSN: 2515-8260

Volume7, Issue9

Study Of Serum Micro-Rna 221 Expression In Patients With Thyroid Nodules And Its Relation To Outcome

    Sherief Samy Bayomy Mohamed Prof. Dr. Raef Malak Botros Prof. Dr. Emad El Din Farid Ibrahim Dr. Alyaa Ahmed ElSherbini Dr. Lamyaa Salem Dr. Hanan Mahmoud Ali

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 9, Pages 577-587

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Abstract

Background: Thyroid nodules are extremely common and are usually benign. 4%-6.5% from thyroid nodulesaremalignant. Among Thyroid cancer investigations manydiagnostic molecular biomarkers were found to have applications in thyroid nodules managment and avoid unnecessary thyroidectomy.(1)
This study aims:To detect value of micro-RNA 221 expression in sera of Patients with thyroid nodules and its relation to outcome after surgery.
Patients and Methods: Forty-five adult subjects aged between 18 to 70-years old who were diagnosed with suspicious thyroid nodules that required total thyroidectomy were offered participation in the study. In addition, five healthy Subjects, were included as a control group, based on the patient’s history, physical examination, US and FNAB findings. Patients who had thyroid nodules with U/S pattern suggestive of malignant potential (TIRADS score ≥ 3),also with indeterminate FNAB results (Bethesda III, IV)were selected. Samples of human plasma were collected from selected patients visiting outpatient clinics. Results was correlated with postoperative pathology results.
Results: In our study there was no significant difference regarding outcome in patients (benign or malignant) with respect to serum microRna 221. There was a significant difference between benign and malignant outcomes regarding size of dominant nodules by ultrasound with a mean value equals 4.6 cm in largest dimension in patients with malignant thyroid nodules and p value equals 0.027 indicating increased size of nodule may be associated with increased risk of malignancy.
Keywords:
    Thyroid Nodules FNA Thyroid malignancy serum microRna 221 thyroid ultrasound Thyroidectomy
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(2020). Study Of Serum Micro-Rna 221 Expression In Patients With Thyroid Nodules And Its Relation To Outcome. European Journal of Molecular & Clinical Medicine, 7(9), 577-587.
Sherief Samy Bayomy Mohamed; Prof. Dr. Raef Malak Botros; Prof. Dr. Emad El Din Farid Ibrahim; Dr. Alyaa Ahmed ElSherbini; Dr. Lamyaa Salem; Dr. Hanan Mahmoud Ali. "Study Of Serum Micro-Rna 221 Expression In Patients With Thyroid Nodules And Its Relation To Outcome". European Journal of Molecular & Clinical Medicine, 7, 9, 2020, 577-587.
(2020). 'Study Of Serum Micro-Rna 221 Expression In Patients With Thyroid Nodules And Its Relation To Outcome', European Journal of Molecular & Clinical Medicine, 7(9), pp. 577-587.
Study Of Serum Micro-Rna 221 Expression In Patients With Thyroid Nodules And Its Relation To Outcome. European Journal of Molecular & Clinical Medicine, 2020; 7(9): 577-587.
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