Development Of Rifampicin Loaded Hyaluronic Acid Coated Chitosan Nanoparticles
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 1, Pages 3447-3458
AbstractThere is a promising potential for nanoparticles in developing controlled and guided drug delivery systems. The most effective formulations are currently considered to be chitosan based nanoparticles; biocompatible, biodegradable, less toxic and simple to use in preparations. Chitosan is a natural biopolymer and has many advantages that can easily be used to achieve the ideal drug delivery mechanism. It is licensed and classified in General Safe (GRAS) by U.S. Food and Drug Administration (USFDA). In the current study, chitosan nanoparticles loaded with Rifampicin were prepared and published in-house. Hyaluronic acid (HA) was coated and further characterized using effective in-vitro methods. The research also included the determination of pharmacokinetic parameters. The findings were confirmatory and can be used to increase the accumulation of medicines.
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