• Register
  • Login

European Journal of Molecular & Clinical Medicine

  • Home
  • Browse
    • Current Issue
    • By Issue
    • By Subject
    • Keyword Index
    • Author Index
    • Indexing Databases XML
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Indexing and Abstracting
    • Peer Review Process
    • News
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
Advanced Search

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 7, Issue 6
  3. Authors

Online ISSN: 2515-8260

Volume7, Issue6

Histopathological Spectrum of Lower Gastro-Intestinal Colonoscopic Biopsy Lesion With Special Reference To Her-2/Neu Expression In Carcinoma Colon

    Debahuti Mohapatra Rupanita Biswal Mitu Mohanty Prateek Das

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1150-1159

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

Introduction :
Cancer associated with colon is one of the principal risk factors from decease in women and men. Although importancegrowing aspect of human epidermis receptor2 (Her2)as atherapeutic target is rising butits role as a biomarker in form of predicting indicator indicatorwithin colorectal cancer(CRC)is stilla mystery.Present research isundertakenfor evaluating the of Her2/neu description in cancer of colon.
Material & Method :
This research comprises 256patientswith spectrum of histopathological treatment ranging from colitis to colorectal carcinoma at our department between 2015- 2017. Her2/neu Immunohistochemistry was done in the colorectal carcinomaand scores based on Ruschoff et al (2012) Her-2 testing in gastric cancer.
Result :
Out of total number of 256 cases enrolled in our study group, majority belonged to the age group of 40-60 years, with M:F ratio being 1.4:1. Commonest site of lesion occurred in rectum (43.75%) followed by ascending colon and caecum (12.08%). Non neoplastic lesions constituted about two third of all cases, the commonest being inflammatory bowel disease(21.48%). In benign neoplastic lesions of tubular adenoma was thecommonest type, and in malignant commonest type was colorectal adenocarcinoma NOS(64.44%) followed by mucinous adeno carcinoma (22.22%). Because of more prominent membranous staining observed in high grade colorectal cancers, Her2neu expression is found to be an important predictive marker of carcinoma colon, especially the adenocarcinoma,NOS.
Conclusion : Like Breast carcinoma, target oriented therapy can be instituted especially in Her 2/neu positive high grade and metastatic tumors.
Keywords:
    Colonoscopic biopsy Inflammatory Bowel Disease Tubulovillous adenoma Colorectal cancer Her2/neu
  • PDF (494 K)
  • XML
(2020). Histopathological Spectrum of Lower Gastro-Intestinal Colonoscopic Biopsy Lesion With Special Reference To Her-2/Neu Expression In Carcinoma Colon. European Journal of Molecular & Clinical Medicine, 7(6), 1150-1159.
Debahuti Mohapatra; Rupanita Biswal; Mitu Mohanty; Prateek Das. "Histopathological Spectrum of Lower Gastro-Intestinal Colonoscopic Biopsy Lesion With Special Reference To Her-2/Neu Expression In Carcinoma Colon". European Journal of Molecular & Clinical Medicine, 7, 6, 2020, 1150-1159.
(2020). 'Histopathological Spectrum of Lower Gastro-Intestinal Colonoscopic Biopsy Lesion With Special Reference To Her-2/Neu Expression In Carcinoma Colon', European Journal of Molecular & Clinical Medicine, 7(6), pp. 1150-1159.
Histopathological Spectrum of Lower Gastro-Intestinal Colonoscopic Biopsy Lesion With Special Reference To Her-2/Neu Expression In Carcinoma Colon. European Journal of Molecular & Clinical Medicine, 2020; 7(6): 1150-1159.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 46
  • PDF Download: 85
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
Journal Information

Publisher:

Email:  info@ejmcm.com

  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap

Editorial Team:  editor@ejmcm.com

For Special Issue Proposal : chiefeditor.ejmcm@gmail.com / info@ejmcm.com

This journal is licensed under a Creative Commons Attribution 4.0 International (CC-BY 4.0)

Powered by eJournalPlus