Features Of Distribution And Density Of Lymphoid Cells Of The Mucosa Of The Larynx As A Manifestation Of Local Immunity In Chronic Laringitis (Analysis Of Sectional Material)
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 3, Pages 2516-2522
AbstractIntroduction: Local immunological manifestations of chronic hyperplastic laryngitis were investigated on the basis of quantitative determination of epithelial-stromal interactions in the mucous membrane of the larynx of subjects having no respiratory problems. Autopsy examination showed that lymphoid cells were nonuniformly distributed in the laryngeal mucous membrane the pattern of distribution depending on the type of epithelium and its integrity, state of the basal membrane, stroma collagen content, and vascularization. The distribution can be viewed as a characteristic of the adaptive potential of the laryngeal mucosa.
Methods: The object of the study was 21 larynx (16 male, 5 female) of people aged 20-65 who died suddenly from causes not associated with the pathology of the respiratory system (acute heart failure, car accident, etc.). The larynx was fixed in 10% neutral formalin, dissected in the longitudinal direction; for histological examination, preparations were left that did not contain macroscopic signs of pathology. The material, after additional fixation in formalin and embedded in paraffin, was stained with hematoxylin and eosin according to Van Gieson, and a PIC reaction was performed. Statistical processing of the results was carried out using the Student's t-test.
Results: The presence of small lymphocytes in the epithelial layer, and in the stroma under the epithelium of immunocompetent cells at different stages of maturation may indicate that a full-fledged immunological reaction is possible in the laryngeal mucosa.
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