European Journal of Molecular & Clinical Medicine

Abstract

Buschke-Lowenstein tumor (verrucous cancer, verrucous carcinoma) is a disease of the anogenital area, with the human papillomavirus (HPV) as the causative agent, mainly of a low-oncogenic type 6 or 11. It is characterized by large cauliflower-type vegetation, progressive invasive growth and at the same time by a benign histological pattern [1-4]. It is a sexually-transmitted infection. This pathology is named after the authors A. Buschke and L. Lowenstein, who first described huge condyloma accuminatum of a penis in 1925. The progression of condyloma accuminatum to the size of a Bushke-Levenstein tumor (BLT) is very rare. This pathology occurs in about 0.1% of sexually active people [5]. Histologically, BLT reveals benign features of a typical condyloma accuminatum (acanthosis, papillomatosis, koilocytosis). Cases of BLT malignancy have been described, but they are extremely rare [6]. Usually BLT develops rather slowly, sometimes within several years, but there have been specified the cases of fast development of BLT with solitary condylomata during pregnancy [7, 8].