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  2. Volume 7, Issue 6
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Online ISSN: 2515-8260

Volume7, Issue6

Evaluation Of Analgesic Activity Of Solid State Forms Of Analgin

    Dr. Poornima B., Dr.S.Varalaxmi , Dr. Bharathi K

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1661-1674

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Abstract

Prevalence and importance of polymorphism occurring in pharmaceutical compounds are well recognized. It is of great importance to prepare and select the right form from the beginning during drug discovery and development. The main objective of the present study is to investigate the polymorphic behavior of Analgin under different preparative conditions and to evaluate the solid forms.
Analgin is amipyrone sulphonate, analgesic, antispasmodic, and antipyretic which is most commonly given orally or parenterally to prevent and treat pain related to surgery or for the treatment of acute pain. No polymorphic forms were reported so far. The solid-state forms of Analgin were developed under different preparative conditions like solvent addition, neat grinding, solvent assisted grinding, cooling, slurrying, etc. Which were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), Scanning electron microscopy (SEM), and Differential scanning calorimetry (DSC).
On slurrying of anlagin by employing methanol and water solvent combination, the input material of analgin containing Form I was partially transformed into Form II, a new solid form. The appearance of new peaks at 4.0 (100), 3.3 (15), 25.5 (10), 29.3 (11), 32.5 (11) and the other peaks at 26.6 (37), 19.6(26), 28.8 (22), and 21.5 (19) corresponding to polymorph 1 indicate that under slurrying conditions the input material of analgin was partially transformed into a new polymorph.
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(2020). Evaluation Of Analgesic Activity Of Solid State Forms Of Analgin. European Journal of Molecular & Clinical Medicine, 7(6), 1661-1674.
Dr. Poornima B., Dr.S.Varalaxmi , Dr. Bharathi K. "Evaluation Of Analgesic Activity Of Solid State Forms Of Analgin". European Journal of Molecular & Clinical Medicine, 7, 6, 2020, 1661-1674.
(2020). 'Evaluation Of Analgesic Activity Of Solid State Forms Of Analgin', European Journal of Molecular & Clinical Medicine, 7(6), pp. 1661-1674.
Evaluation Of Analgesic Activity Of Solid State Forms Of Analgin. European Journal of Molecular & Clinical Medicine, 2020; 7(6): 1661-1674.
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