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  2. Volume 7, Issue 6
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Online ISSN: 2515-8260

Volume7, Issue6

A Non-Covalent Bonding Interaction Between Amitriptyline And Beta-Cyclodextrin: Comparisons Of In-Vitro Cytotoxic Activity Against Breast Cancer Cell Line

    Muthusamy Viswalingam, Moorthiraman Murugan, Samikannu Prabu, Krishnamoorthy Sivakumar, Anitha Arumugam, Rajaram Rajamohan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 6, Pages 1698-1705

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Abstract

The formation of supramolecular host-guest inclusion complex of amitriptyline [AP] and b-Cyclodextrin [b-CD] have been studied in solution state. The stoichiometric ratio of the inclusion complexes between AP and b-CD in solution state is confirmed by the absorption and fluorescence spectroscopic tehniques.  The binding constant value has been calculated for the 1:1 complex by using Benesi-Hildebrand equation. An in-vitro cytotoxic performance also checked for pure AP and its inclusion complex with b-CD and the inclusion complex clearly had shown that the no change after making AP towards inclusion complex with b-CD.
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(2020). A Non-Covalent Bonding Interaction Between Amitriptyline And Beta-Cyclodextrin: Comparisons Of In-Vitro Cytotoxic Activity Against Breast Cancer Cell Line. European Journal of Molecular & Clinical Medicine, 7(6), 1698-1705.
Muthusamy Viswalingam, Moorthiraman Murugan, Samikannu Prabu, Krishnamoorthy Sivakumar, Anitha Arumugam, Rajaram Rajamohan. "A Non-Covalent Bonding Interaction Between Amitriptyline And Beta-Cyclodextrin: Comparisons Of In-Vitro Cytotoxic Activity Against Breast Cancer Cell Line". European Journal of Molecular & Clinical Medicine, 7, 6, 2020, 1698-1705.
(2020). 'A Non-Covalent Bonding Interaction Between Amitriptyline And Beta-Cyclodextrin: Comparisons Of In-Vitro Cytotoxic Activity Against Breast Cancer Cell Line', European Journal of Molecular & Clinical Medicine, 7(6), pp. 1698-1705.
A Non-Covalent Bonding Interaction Between Amitriptyline And Beta-Cyclodextrin: Comparisons Of In-Vitro Cytotoxic Activity Against Breast Cancer Cell Line. European Journal of Molecular & Clinical Medicine, 2020; 7(6): 1698-1705.
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