A Non-Covalent Bonding Interaction Between Amitriptyline And Beta-Cyclodextrin: Comparisons Of In-Vitro Cytotoxic Activity Against Breast Cancer Cell Line
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 6, Pages 1698-1705
Abstract
The formation of supramolecular host-guest inclusion complex of amitriptyline [AP] and b-Cyclodextrin [b-CD] have been studied in solution state. The stoichiometric ratio of the inclusion complexes between AP and b-CD in solution state is confirmed by the absorption and fluorescence spectroscopic tehniques. The binding constant value has been calculated for the 1:1 complex by using Benesi-Hildebrand equation. An in-vitro cytotoxic performance also checked for pure AP and its inclusion complex with b-CD and the inclusion complex clearly had shown that the no change after making AP towards inclusion complex with b-CD.
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