• Register
  • Login

European Journal of Molecular & Clinical Medicine

  1. Home
  2. A Comparative Study on Efficacy of Tamsulosin, Finasteride and Combination Therapy in Patients with Benign Prostatic Hyperplasia

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Editorial Board

Publication Ethics

Indexing and Abstracting

Related Links

FAQ

Peer Review Process

Journal Metrics

News

A Comparative Study on Efficacy of Tamsulosin, Finasteride and Combination Therapy in Patients with Benign Prostatic Hyperplasia

    Author

    • KALAIVANI R, SARANYA P, MANOJKUMAR RAJA M

    Pharm. D. Alumni, SPS, VISTAS

,

Document Type : Research Article

  • Article Information
  • Download
  • Export Citation
  • Statistics
  • Share

Abstract

Context: Benign prostatic hypertrophy (BPH) is a common condition that can result in bothersome lower urinary tract symptoms.
Aims: The study aimed to determine the efficacy of tamsulosin, finasteride and combination therapy in patients with benign prostatic hyperplasia and to observe the quality of life in all the 3groups.
Settings and Design: A prospective observational study was carried out in the department of surgery of a tertiary care hospital.
Methods and Material: Benign prostatic hyperplasia (BPH) patients who fulfilled the inclusion and exclusion criteria were enrolled into the study and were assigned to any one of the 3 groups randomly, G1-Tamsulosin, G2-finasteride and G3-combination therapy (tamsulosin + dutasteride). Patients were monitored during the hospital stay and followed up until discharge. Severity of symptoms was observed by administering AUA symptom score questionnaire either in English or in tamil.
Statistical analysis used: All statistical analysis was performed using SPSS 17.0 and graph pad prism 7.0. Unpaired student t –test was used to compare two groups and p value less than 0.05 was considered statistically significant throughout the study (95% of confidence interval).
Results: A total of 120 patients, most of the age group ranging from 61-70 yrs  (54.16%). There were no significant differences in baseline characteristics. There was significant differences in group wise pre and post drug therapy (p<0.0001) and the treatment efficacy was not similar between the treatment groups (P <0.05).
Conclusion:Combinational therapy was observed to be more efficacious than monotherapy with either tamsulosin or finasteride therapy. Hence it is recommended that combinational therapy can be preferred over monotherapy in the management of BPH in elderly males with or without over active bladder.

  • XML
  • PDF 408.92 K
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
    • Article View: 212
    • PDF Download: 576
European Journal of Molecular & Clinical Medicine
Volume 7, Issue 6
November 2020
Page 1989-1998
Files
  • XML
  • PDF 408.92 K
Share
Export Citation
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
Statistics
  • Article View: 212
  • PDF Download: 576

APA

MANOJKUMAR RAJA M, K. R. S. P. (2020). A Comparative Study on Efficacy of Tamsulosin, Finasteride and Combination Therapy in Patients with Benign Prostatic Hyperplasia. European Journal of Molecular & Clinical Medicine, 7(6), 1989-1998.

MLA

KALAIVANI R, SARANYA P, MANOJKUMAR RAJA M. "A Comparative Study on Efficacy of Tamsulosin, Finasteride and Combination Therapy in Patients with Benign Prostatic Hyperplasia". European Journal of Molecular & Clinical Medicine, 7, 6, 2020, 1989-1998.

HARVARD

MANOJKUMAR RAJA M, K. R. S. P. (2020). 'A Comparative Study on Efficacy of Tamsulosin, Finasteride and Combination Therapy in Patients with Benign Prostatic Hyperplasia', European Journal of Molecular & Clinical Medicine, 7(6), pp. 1989-1998.

VANCOUVER

MANOJKUMAR RAJA M, K. R. S. P. A Comparative Study on Efficacy of Tamsulosin, Finasteride and Combination Therapy in Patients with Benign Prostatic Hyperplasia. European Journal of Molecular & Clinical Medicine, 2020; 7(6): 1989-1998.

  • Home
  • About Journal
  • Editorial Board
  • Submit Manuscript
  • Contact Us
  • Glossary
  • Sitemap

News

 

For Special Issue Proposal : editor.ejmcm21@gmail.com

Newsletter Subscription

Subscribe to the journal newsletter and receive the latest news and updates

© Journal Management System. Powered by ejournalplus