European Journal of Molecular & Clinical Medicine

Abstract

Placenta is an important organ which is necessary for the intrauterine growth of foetus.complications .due to Pregnancy like hypertension(PIH) affects the placenta and is the major factor to cause maternal & foetal death.
Objectives:1. To study the morphological and histological features of placenta in normal and hypertensive patients . 2.To Compare the two groups and study the correlation of their changes with the foetal outcome.
Material & Methods: 100 specimens of placentas of patients from normal as well as hypertensive group were collected from the labour room & operation theatre of Dept. of Obstetric & Gynaecology of Dr. Panjabrao Deshmukh Medical College and hospital, Amravati, Maharashtra .At first the gross features ( morphological features) of placentas were observed.. To study the histology , sections from each placenta of size 5mm were taken. This was fixed in in 10% formal saline and further histological processing of the tissue was carried out.
Observations & Results: The gross morphological features like weight, size, surface area, number of cotyledons were reduced and areas of infarction, retroplacental clot, calcification were increase in hypertensive placenta than normal placenta. (p<0.005) Similarly, the histological features like increased syncytial knots, intravillous and intervillous fibrin deposition, cytotrophoblastic proliferation, hyalinised villi, atherosis were observed in hypertensive placentas. These all changes were correlated with the foetal mortality and morbidity. And we observed that there was increase in foetal mortality and morbidity in hypertensive patients with the above histological changes in their placentas.