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Advanced Glycation End-Products In Diabetes Complications

    Authors

    • Anush N 1
    • Bineesh C. P. 2
    • Jeena Gupta 3
    • Pranav Kumar Prabhakar 2

    1 Vocational Teacher in MLT, Sree Narayana Vocational Higher secondary School, Sreekanteswaram, Cherthala, Kerala, India-688526

    2 School of Applied Medical Science, Lovely Professional University, Phagwara Punjab-144411

    3 Department of Biochemistry, Lovely Professional University Punjab, India 144411

,

Document Type : Research Article

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Abstract

Diabetic complications, such as, retinopathy, nephropathy lead to blindness and end stage renal failure respectively, various neuropathies, and ultimately increased mortality. While the exact mechanisms that lie behind the pathological changes associated with diabetes remain obscure, however, it is widely believed that chronic or intermittent hyperglycemia may alter various metabolic pathways at the tissue level, for instance, increased flux through the polyol and the hexosamine pathways as well as a persistent activation of protein kinase C (PKC). Reducing sugars such as glucose and fructose may react non-enzymatically through their carbonyl groups with free amino groups of proteins (commonly the Ɛ amino group of lysine) to form a Schiff base intermediate which then rearranges to a more stable structure known as Amadori product. The Amadori products generated by the aforementioned Maillard reaction may then undergo further reactions, including dehydration, oxidation and rearrangement resulting in the irreversible formation of heterogeneous advanced glycation end products (AGEs)

Keywords

  • Diabetes
  • protein kinase
  • complications
  • Hyperglycemia
  • Glucose
  • hexosamine
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 7
November 2020
Page 2190-2198
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  • Article View: 269
  • PDF Download: 311

APA

N, A., C. P., B., Gupta, J., & Prabhakar, P. K. (2020). Advanced Glycation End-Products In Diabetes Complications. European Journal of Molecular & Clinical Medicine, 7(7), 2190-2198.

MLA

Anush N; Bineesh C. P.; Jeena Gupta; Pranav Kumar Prabhakar. "Advanced Glycation End-Products In Diabetes Complications". European Journal of Molecular & Clinical Medicine, 7, 7, 2020, 2190-2198.

HARVARD

N, A., C. P., B., Gupta, J., Prabhakar, P. K. (2020). 'Advanced Glycation End-Products In Diabetes Complications', European Journal of Molecular & Clinical Medicine, 7(7), pp. 2190-2198.

VANCOUVER

N, A., C. P., B., Gupta, J., Prabhakar, P. K. Advanced Glycation End-Products In Diabetes Complications. European Journal of Molecular & Clinical Medicine, 2020; 7(7): 2190-2198.

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