European Journal of Molecular & Clinical Medicine

Abstract

Objective:The motive of the currentworkwas to Preparation and Characterization of Immediate Release film coated tablets Valsartan -Hydrochlorothiazide (160/12.5mg) to reduce the multiple dosing and to achieve more effective reduction of hypertension.
Background: The oral route is the very effective and favoured method for the introduction of medications to systemic circulation because of ease of diagnosis, patient compliance and flexibility.
Materials and Methods: Valsartan - Hydrochlorothiazide tablet tends to film coated to prevent the drug from degradation. Preliminary studies were performed out with the excipients and the drug and their physical & chemical compatibilities were checked and the drugs and they found compatible.The method of preparation was the wet granulation method.
Results:A maximum of nine formulation batches (f1-f9) have been prepared.Prepared formulations have also been tested for weight variance, friability, disintegration, analysis, in vitro drug release profile.The criteria tested are contained within the guidelines.The parameters tested were found within the limits. Among all formulations, the product of batch f9 has acceptable friability, assay and dissolution profile. It was further exposed to an advanced stability test at 40±20C/75±5 per cent RH.