European Journal of Molecular & Clinical Medicine

Abstract

The aim of the research was to study the occurrence of autoimmune processes in chronic
hepatitis and its effect on the hematological parameters of the mother and offspring in the
dynamics of lactation. Material and research methods - the work was carried out on white
outbred female rats, in which, after heliotrine intoxication before pregnancy, the presence of
antihepatic antibodies in female rats was carried out by a passive hem agglutination reaction
according to Boyden's method, as well as hematological parameters in the mother and
offspring in the dynamics of lactation by conventional methods. The presence of
antihepatocytic autoantibodies during lactation was established, mainly in blood serum, and in
small amounts in the milk of female rats, therefore, antihepatic antibodies of the mother in
toxic hepatitis are not a pathological agent for offspring during breastfeeding. In the body of
female rats and offspring, anemia develops, progressing until the second week of lactation,
that is, the transition of pups to a mixed diet, therefore, it is more expedient to carry out
therapeutic measures before this period.