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  2. Volume 7, Issue 3
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Online ISSN: 2515-8260

Volume7, Issue3

Comparison Of The Effectiveness Of Alpha-Tocopherol And Ginkgo Biloba Extract On The Prevention Of Ototoxic Kanamycin In The Treatment Of Multiple Drug-Resistant Tuberculosis

    Fransiskus Harf Poluan

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 3, Pages 4736-4751

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Abstract

Introduction: Ototoxic due to kanamycin which resulting sensorineural hearing loss is one of the effects of kanamycin. Antioxidant treatment could prevent the effects of ototoxic. Aim: To compare the effectiveness of Ginkgo Biloba and alpha-tocopherol on prevention incidence of ototoxic due to kanamycin for MDR TB patients. Method: An experimental study in dr. Hasan Sadikin Hospital on July - October 2016, followed by 32 subjects were divided into two groups of patients, 16 subjects were given Ginkgo Biloba (EGB 761), and 16 subjects were given alpha-tocopherol. Examination of ototoxic by using the audiogram and DPOAE. Statistical analysis for this study using the chi-square test. Interpretation of the results of hypothesis testing based on the value of p <0.05. Result: Subjects in group Ginkgo Biloba experience less in hearing loss than alpha-tocopherol group after three weeks post-treatment based on an audiogram (p = 0.048) and DPOAE at a frequency of >8-10 kHz(0.001) and >6-8 kHz (0.014). After four weeks post-treatment group EGB 761 on DPOAE examination less experienced hearing loss at a frequency of >8-10 kHz (0.000) and >6-8 kHz (0.022). Conclusion: Ginkgo Biloba is more effective in preventing ototoxic due to kanamycin in patients with MDR TB than alpha-tocopherol. Giving Ginkgo Biloba can be used as therapy protocols in preventing sensorineural hearing disorders in patients with MDR TB who treated with kanamycin.
Keywords:
    kanamycin MDR TB Ginkgo Biloba alpha-tocopherol
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(2020). Comparison Of The Effectiveness Of Alpha-Tocopherol And Ginkgo Biloba Extract On The Prevention Of Ototoxic Kanamycin In The Treatment Of Multiple Drug-Resistant Tuberculosis. European Journal of Molecular & Clinical Medicine, 7(3), 4736-4751.
Fransiskus Harf Poluan. "Comparison Of The Effectiveness Of Alpha-Tocopherol And Ginkgo Biloba Extract On The Prevention Of Ototoxic Kanamycin In The Treatment Of Multiple Drug-Resistant Tuberculosis". European Journal of Molecular & Clinical Medicine, 7, 3, 2020, 4736-4751.
(2020). 'Comparison Of The Effectiveness Of Alpha-Tocopherol And Ginkgo Biloba Extract On The Prevention Of Ototoxic Kanamycin In The Treatment Of Multiple Drug-Resistant Tuberculosis', European Journal of Molecular & Clinical Medicine, 7(3), pp. 4736-4751.
Comparison Of The Effectiveness Of Alpha-Tocopherol And Ginkgo Biloba Extract On The Prevention Of Ototoxic Kanamycin In The Treatment Of Multiple Drug-Resistant Tuberculosis. European Journal of Molecular & Clinical Medicine, 2020; 7(3): 4736-4751.
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