Synthesis, Characterization And Study Of Oxadiazole Derivatives For Potent Antimicrobial Activity
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 7, Pages 3757-3769
AbstractFour new oxadiazole derivatives, 5-(2-chlorophenyl)-1, 3, 4-oxadiazole-2-amine, 5-(3-nitrophenyl)-1, 3, 4-oxadiazole-2-amine, 4-(5-amino-1, 3, 4-oxadiazole-2-yl)phenol, 5-(3,4-dimethoxyphenyl)-1, 3, 4-oxadiazole-2-amine have been synthesized, characterized and studied for in-vitro antimicrobial activities. The antibacterial studies is carried out against bacteria E.coli, Bacillus subtilis, Micrococcus letteus and the anti-fungal studies is carried out against fungus candida albicans, Sacromyces cervesiae at concentrations 50μg/ml, 100 μg/ml and 150μg/ml. The potency of the derivatives is analysed against standard antibiotic drug ampicillin at 100μg/ml. Compounds 5-(2-chlorophenyl)-1, 3, 4-oxadiazole-2-amine and 5-(3,4-dimethoxyphenyl)-1, 3, 4-oxadiazole-2-amine are found more effective than ampicillin, which may be explored as new analogues in antibiotic category.
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