European Journal of Molecular & Clinical Medicine

Abstract

Previous studies showed patients with mild hypothyroidism, mainly elderly women, are at a higher risk of cardiovascular diseases because of lipid abnormalities. This study is conducted to find predominanceof subclinical hypothyroidism in apparently healthy patients and to determine, either hypercholesterolemia is common insubclinical hypothyroidismpatients or inindividuals with euthyroid. This observational study was conducted in Government Medical College, Jammu (Department of Biochemistry) over a period of four months.Biochemical investigations for thyroid function and lipid profile were conducted on 150 patients of either sex, aged 18 to 85 years. Based on serum TSH values, patients were divided into SCH (n=53) and EU group (n=97).
Quantitative variables were calculated and statistical significant result was considered for p-value less than 0.05.TSH valuesfound to be elevated in individuals with subclinical hypothyroidism. Similarly, serum TC and triglyceridesfound significantly elevated in SCH group than in EU group. On perspective of age, average total cholesterol values were elevated in all age-groups of SCH group. This study conclude that in SCH group, there is an increase in levels of atherogenic lipids, especially total cholesterol (TC). Female patients as well as patients with>60 years are pronetohypercholesterolemia, which suggests that all adults above 35 years with subclinical hypothyroidism should be asked to get their lipid profile investigated.