European Journal of Molecular & Clinical Medicine

Abstract

Fisetin is a polyphenolic compound which is a dietary flavonoid and mostly found in fruits, vegetables, seeds, nuts, tea etc. It faces a major challenge of poor aqueous solubility and poor bioavailability. To improve the dissolution rate, we have prepared liquisolid powder of fisetin. Liquisolid powder, batch F1 to F3 were formulated. Among them formulation F2 has shown good results. It contained, fisetin 0.30g, tween-80 6g, Aerosil 200 5g, and Lactose 3g. Formulation F2 showed very good micromeritic properties such as angle of repose, bulk density and Carr’s index. Hence, the study indicated successful development of liquisolid powder of fisetin. The dissolution study showed increase in dissolution rate of fisetin from liquisolid powder as compared to that of pure fisetin.