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Role Of Increasing Levels Of The Hormone Cortisol In Cognitive Impairment In Parkinson's Disease: Vascular Parkinsonism

    Authors

    • Gulnora Sattarovna Rakhimbaeva 1
    • Dilshoda Turdikulovna Akramova 2

    1 Department of Neurology, Tashkent Medical Academy, Republic of Uzbekistan Contact information: Akramova D.T,

    2 Tashkent Medical Academy, Farobi Street 2, Tashkent, Republic of Uzbekistan,

,

Document Type : Research Article

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Abstract

This article is based on a review of the literature and recent clinical studies on changes in plasma cortisol hormone concentrations in cognitive impairment in Parkinson's disease. The article presents the reasons for the relationship between cognitive impairment in Parkinson's disease, in particular vascular Parkinsonism and neurodegenerative diseases, as well as the results of neuropsychological tests.
Methods: We studied the level of morning plasma cortisol in 68 patients with Vascular Parkinsonism (VP) who were hospitalized in 1st neurology department of TMA in the period from 2015 to the present.The relationship between increased morning plasma cortisol and cognitive impairment was determined.The results of the study were statistically analyzed.Cortisol was determined in all blood samples of patients of the Main and Control groups.The control group consisted of 47 volunteers.
Results: Normal levels of cortisol were observed in 20 patients (29%) with vascular parkinsonism,, moderate increases in cortisol were observed in 37 patients (54.4%), and elevations in cortisol were observed in 11 patients (16.1%). Was determined the relationship between the value of cortisol and the assessment of cognitive impairment.In the main group, a statistically significant moderate inverse correlation was determined between plasma cortisol level and cognitive impairment in VP. When studying cortisol levels in VP, its significant increase is noted than in the control (p <0.05).
Conclusion: Increased levels of the hormone cortisol in Parkinson's disease play an important role in cognitive impairment and during the course of the disease and affect the effectiveness of VP therapy.

Keywords

  • Parkinson's disease
  • Vascular Parkinsonism
  • cortisol hormone
  • cognitive disorders
  • circadian rhythm
  • hippocampal mineralocorticoid receptors
  • depression
  • stress
  • subthalamic nucleus
  • deep brain stimulation
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European Journal of Molecular & Clinical Medicine
Volume 7, Issue 6
November 2020
Page 2987-2994
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APA

Rakhimbaeva, G. S., & Akramova, D. T. (2020). Role Of Increasing Levels Of The Hormone Cortisol In Cognitive Impairment In Parkinson's Disease: Vascular Parkinsonism. European Journal of Molecular & Clinical Medicine, 7(6), 2987-2994.

MLA

Gulnora Sattarovna Rakhimbaeva; Dilshoda Turdikulovna Akramova. "Role Of Increasing Levels Of The Hormone Cortisol In Cognitive Impairment In Parkinson's Disease: Vascular Parkinsonism". European Journal of Molecular & Clinical Medicine, 7, 6, 2020, 2987-2994.

HARVARD

Rakhimbaeva, G. S., Akramova, D. T. (2020). 'Role Of Increasing Levels Of The Hormone Cortisol In Cognitive Impairment In Parkinson's Disease: Vascular Parkinsonism', European Journal of Molecular & Clinical Medicine, 7(6), pp. 2987-2994.

VANCOUVER

Rakhimbaeva, G. S., Akramova, D. T. Role Of Increasing Levels Of The Hormone Cortisol In Cognitive Impairment In Parkinson's Disease: Vascular Parkinsonism. European Journal of Molecular & Clinical Medicine, 2020; 7(6): 2987-2994.

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