Glycated Albumin as a Prognostic Indicator of Cardiovascular Events in Patients with Diabetic Nephropathy
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 1404-1415
AbstractIntroduction: Diabetic Asian Indians compared to westerners are highly prone to end-organ complications resulting in mortality. Few studies are being done in India to assess cardiac complications in diabetic nephropathy. This study was done to evaluate the role of glycated albumin in assessing cardiovascular events in diabetic nephropathy patients.
Materials and methods: The study was conducted at Sri Ramachandra Medical College and Research Institute, Chennai and G.S.L.Medical College and Hospital, Rajahmundry. This case control study included 170 participants of 45 to 60 years old from both sexes. Study had four groups; group I: 45 nondiabetic apparently healthy individuals, Groups II, III and IV individuals who had type 2 diabetes mellitus for atleast five years; 45 diabetics with normoalbuminuria, 40 diabetics with microalbuminuria and 40 diabetics with macroalbuminuria in groups II to IV respectively. The study was approved by ethics committees of both the institutes. Written informed consent was obtained. HbA1c and glycated albumin were analyzed by immunoturbidometry, ion exchange chromatography and ELISA respectively. The obtained data were checked for normal distribution. Appropriate statistical tools were used; P value less than 0.05 was considered statistically significant. The statistical analyses were performed in SPSS software version 16.0.
Results: There was significant increase in glycated albumin. There was a positive correlation between GA and HbA1c. The cutoff level of GA was 176.50pmol/mL.
Conclusion: Glycated albumin is a good prognostic indicator of carotid artery atherosclerosis, retinopathy and postprandial hyperglycemia. Glycated albumin levels can assess the cardiovascular events in diabetic nephropathy.
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