Synthesis, antimicrobial assays and docking study of new triazolo cum tetrazolo quinoline derivatives.
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 9, Pages 1996-2010
AbstractA series of triazolo cum tetrazoloquinoline derivatives viz 4-((4-phenyl 1H-1,2,3 triazol 1 yl)-methyl) tetrazolo [1,5-a] quinoline derivatives (4a-g) were synthesized utilizing 1,3-dipolar cycloaddition (click chemistry) reaction of 4-(azido-methyl) tetrazolo [1,5-a] quinoline derivatives (3a-3g) with alkyne hydrocarbon containing a phenyl group using copper (I) catalyst has been achieved in good yield. In vitro antimicrobial assays of all corresponding synthesized derivatives were performed. Significant antimicrobial activity observed against all the tested strains for majority of the synthesized compounds. From the results of biological activity and docking study it is observed that the Novel triazolo cum tetrazoloquinoline derivatives 4b, 4d and 4f can serve as important lead moiety for further exploration.
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