SPECTROPHOTOMETRIC SIMULTANEOUS DETERMINATION OF CHLORZOXAZONE AND DICLOFENAC SODIUM IN TABLET DOSAGE FORM
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 9, Pages 2033-2039
AbstractThe aim of the study to describe a simple, precise sensitive, rapid, accurate and economical simultaneous equation method for the determination of chlorzoxazone and diclofenac sodium in tablet dosage form. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths 244nm and 280nm. The proposed method was validated for linearity, accuracy and precision. The linearity was obtained in the concentration range 5- 20 µg/mL for Chlorzoxazone and 1- 4µg/mL for Diclofenac sodium. The percentage recovery was found to be 98 - 101% for Chlorzoxazoneand 98 – 100% for Diclofenac sodium indicates that the method was accurate and precise for simultaneous estimation of Chlorzoxazone and Diclofenac sodium in tablets.
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