A Self-Controlled Prospective Study Between Methylprednisolone And Dexamethasone Inter-Laminar Epidural Steroid Injection In Radicular Pain For Prolapse Intervertebral Disc In Lumber Vertebrae.
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 1, Pages 37-42
Abstract
Introduction :Previous studies have shown varying results with trans-foraminalapproach epidural steroidinjections performed with particulate versus non-particulate corticosteroids. The purpose of this study was to investigate the difference in pain relief and functional improvement between particulate and non-particulate lumbosacral (MIL) in patients who had undergone both injections through intra-laminar approach.
Methods:
This was a self-controlled, prospective study of 40 patients who underwent both a methylprednisolone and a dexamethasone intra-laminar injection to the same vertebral level and side. Primary outcomes included pain relief according to the visual analogue scale (VAS) and functional improvement determined by a yes/no answer to questions regarding mobility and the activities of daily living. Post-injection data was recorded at 6, 12, and 24 weeks.
Results:
A decrease in VAS scores of-3.6 +/- 3, - 3.2 +/- 3.2, -3 +/- 3.1 is noted in methyl prednisolone group as compared to better VAS score projected in patients with dexamethasone group as suggested -3.9+/- 3.2, -3.1 +/- 2.9,- 2.2 +/- 3.2 at 6 weeks, 12 weeks and 24 weeks respectively.
Conclusions:
Introduction :
Previous studies have shown varying results with trans-foraminalapproach epidural steroidinjections performed with particulate versus non-particulate corticosteroids. The purpose of this study was to investigate the difference in pain relief and functional improvement between particulate and non-particulate lumbosacral (MIL) in patients who had undergone both injections through intra-laminar approach.
Methods:
This was a self-controlled, prospective study of 40 patients who underwent both a methylprednisolone and a dexamethasone intra-laminar injection to the same vertebral level and side. Primary outcomes included pain relief according to the visual analogue scale (VAS) and functional improvement determined by a yes/no answer to questions regarding mobility and the activities of daily living. Post-injection data was recorded at 6, 12, and 24 weeks.
Results:
A decrease in VAS scores of-3.6 +/- 3, - 3.2 +/- 3.2, -3 +/- 3.1 is noted in methyl prednisolone group as compared to better VAS score projected in patients with dexamethasone group as suggested -3.9+/- 3.2, -3.1 +/- 2.9,- 2.2 +/- 3.2 at 6 weeks, 12 weeks and 24 weeks respectively.
Conclusions:
Findings positively supports the use of non-particulate steroids for lumbar prolapse inter-vertebral disc with radicular pain in contrast of safety use of particulate steroids for one of treatment modality in dealing with localized or radicular pain
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