To Assess Hba1c In Non Diabetic Subclinical Hypothyroidism Patients
European Journal of Molecular & Clinical Medicine,
2021, Volume 8, Issue 1, Pages 308-313
AbstractIntroduction: India has the highest prevalence of prediabetes, hypothyroidism, and diabetes. In females, subclinical hypothyroidism (SH) is more prevalent than in men. Studies in non-diabetic hypothyroid patients have reported elevated HbA1c. Standard serum triiodothyronine (T3), thyroxine (T4) and serum thyroid stimulating hormone (TSH) levels dropping from 4.2 to 10 (mIU/L) are classified as SH.
Aim: To study the HbA1c level in the non-diabetic SH patients and to compare the HbA1c level with the controls.
Materials and Methods:This study was a case-control study conducted between September 2020 and November 2020 in the Department of Medicine at DMMC & SMHRC, Nagpur in collaboration with ABVRH, Sawangi (Meghe). For the analysis, a total of 120 participants were considered, 60 in each case and 60 in the control groups. Parents and friends of patients who were matched by age and sex were monitored.
Results: Since there was no statistically significant difference in age, sex, FBS, haemoglobin, serum T3 and serum T4 levels between the case group with subclinical hypothyroidism and the control group with normal healthy subjects, the only difference between the case and control groups was serum TSH levels.
Conclusion:Our data suggest that the non-diabetic subjects with SH show high levels of the HbA1c. Therefore, the effect of altered levels of the serum TSH on the HbA1c must be considered when interpreting the HbA1c for the diagnosis of diabetes in the SH patients
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