European Journal of Molecular & Clinical Medicine

Abstract

Background:Hypothyroidism,is a common endocrine disorder manifestingwith altered mineral metabolism.Hence we designed this research to compare the levels of total and ionised calcium in postmenopausal women with thyroid dysfunction. Materials and methods:This is a case control study with 75 hypothyroid postmenopausal women and 25euthyroids.Triiodothyronine(T3),Thyroxine(T4) level, Thyroid stimulating hormone(TSH)and serum total and ionised calcium were analysed. Statistical analysis was done using SPSS software.Results:Postmenopausal women with hypothyroidism showed a significant reduction in total and ionised calcium levels with increase in duration of disease. Correlation analysis with calcium (total and ionised) showed a significant negative correlation for TSH and positive correlation for T3 and T4.Conclusion:Decrease in total and ionised calcium level in postmenopausal women with hypothyroidism was observed in our study. It was considered to be due to reduced intestinal absorption and increased renal loss which is worsened by dysfunctional thyroid. Evaluation of mineral status in hypothyroidism may support early prediction and prevention of osteoporosis in postmenopausal population.