European Journal of Molecular & Clinical Medicine

Abstract

The main objective of the study is to analyze the adverse drug reactions (ADRs)reported in our hospital and assess them using standard assessment scales. A total of 100 adverse drug reactions were analysed after screening for inclusion and exclusion criteria. The study had 59% of males and 41% of females mostly belonging to age group of 40-60 years. Maximum adverse drug reactions were reported in General Medicine Department (22). Among the various drug groups, antibiotics caused the most adverse drug reactions (45) followed by anti-tubercular drug regimen (15) and Gastro intestinal drugs (14). The most commonly reported antibiotics were ciprofloxacin (19) followed by cefixime (6) and cefotaxime (4), piperacillin +tazobactam (3) , clindamycin(2) , vancomycin (6), amoxicillin + potassium clavulanate(3) and metronidazole (2). Ranitidine (14), Drotaverin (3) , levetiracetam (5), ringer lactate (3) injection ferric carboxymaltose (3) are the most commonly reported gastrointestinal, analgesic, anticonvulsant, I.v fluid and vitamin supplements to cause adverse effects respectively. The maximum adverse effects were reported by the drugs that are administered through parenteral route (83). The most commonly reported adverse effects were dermatological signs and symptoms likes rashes, itching redness etc.in about 88%patients. The causality, type of ADRs and severity were assessed using standard assessment scales. According to the respective assessment scales, the majority of the ADRs reported were probable (71%) type B reactions (68%) and mild in nature. (58%). Hence, this study serves as a database of adverse drug reactions reported in our hospital which could provide an important resource for clinicians to update their knowledge regarding the importance of ADRs monitoring and reporting and strict vigilant use of drugs which will ultimately lead to improved patient care.