“A Comparative Study Between Injection Dexmedetomidine And Injection Fentanyl As An Adjuvant To Intrathecal Isobaric Ropivacaine0.75% For Lower Abdominal Surgeries."
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 3523-3530
AbstractBackground: Spinal anesthesia a form of regional anesthesia which is commonly used intraoperatively. Local anaesthetics are of short duration of action. Adjuvants are used for prolongation of postoperative analgesia. The vulnerability of nerve fibres to local anaesthetic inhibition is affected by axonal diameter. Period of action correlates with lipid solubility and potency. There are longer durations of action of lipid soluble local anaesthetics, because they diffuse from a lipid rich one more slowly, to the aqueous bloodstream environment.
Objectives: To examine efficacy of dexmedetomidine and fentanyl while giving intrathecally as an adjuvant to 3 ml of 0.75 percent isobaric ropivacaine.
Materials and Methods: 80 patients will be randomized to receive 3 ml of 0.75 percent isobaric ropivacaine with dexmedetomidine 10 mcg (Group RD) or 20 mcg of fentanyl (Group RF) intrathecally for lower abdominal surgeries, block characteristics, hemodynamic changes, and side effects will be compared.
Results: The effectiveness of both medications was studied when intrathecally administered. The mean time needed in Group RD and group RD for sensory blockade at T10 was 156.466± 33.78 s.In Group RF, 185.200± 35.17 s. The findings are clinically and statistically significant (P0.002). Mean of total sensory block length in Group RD it was 194.400 min, while in Group RF it was 139.90 min, which was clinically and statistically significant (P-0.0001). The total motor block in group RD was 136.73 minutes. Where as in group RF it is clinically and statistically significant(p-0.000) and it is 94.866 minutes.
Conclusion: The 10μg dose of dexmedetomidine added to 3ml of 0.75 percent isobaric ropivacaine produced earlier sensory blockade, prolonged sensory and motor blockade and improved sedation and post-operative analgesia under spinal analgesia in lower abdominal surgeries.
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