A Prospective Analysis Of Diagnostic Accuracy Of High Sensitive C- Reactive Protein In Neonatal Sepsis
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 3780-3787
AbstractBackground: Neonatal sepsis is an entity that involves blood stream infections associated with systemic symptoms in the first month after birth. Amongst the various types of sepsis in babies, it can be clinical which presents with characteristic symptoms, probable sepsis when clinical symptoms are also associated with positive lab findings and culture positive sepsis where in addition to the above blood culture would also be positive to infectious organism. Septicemia in a baby less than 28 days can also be classified into early and late onset depending on the time after birth that it presents. Early onset sepsis presents within 72 hours of birth and late onset presents after 72 hours of life. Diagnosing sepsis early is of prime importance to cut down the irrational use of higher antibiotics in culture negative neonates. This will not only curb drug resistant strains but also bring down the cost of intervention.
Aim: The main aim of our study is to measure the efficacy of high sensitive CRP (hs-CRP) in early diagnosis of neonatal sepsis.
Objectives: To determine diagnostic accuracy of hs-CRP in detecting neonatal sepsis.
Methodology: Ours will be a prospective cross sectional study where we will take two serial measurements of hs-CRP in clinically septic neonates and corelate the values with respect to other conventional screening markers like blood indices and CRP to determine its efficacy, sensitivity and specificity in detecting neonatal sepsis early. Blood culture will be taken as a gold standard to prove sepsis.
Expected Result: We expect hs-CRP to be more sensitive in detecting neonatal sepsis earlier than conventional sepsis screen of our center.
Conclusion: If proven effective in detecting sepsis early, this study could aid in the future incorporation of hs-CRP as part of routine screening of neonates for sepsis.
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