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  2. Volume 7, Issue 11
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Online ISSN: 2515-8260

Volume7, Issue11

A Comparative Pilot Study on The Effect of Intracavernosal Injection Of (Papaverine/Verapamil) And (Papaverine/Phentolamine) In Erectile Dysfunction Patients

    Mohamed Farid Roaiah, Ahmed Raef Sadek, Ahmed Mohamed Gamal, Mohamed Ahmed Abd El Salam

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 4074-4081

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Abstract

Background: Intracavernosal injection (ICI) as a locally acting therapeutic modality has been tried since early 70s for the treatment of ED. Several vasoactive substances have been tried either a mono-therapy or in combination (i.e. Bimix or Trimix); whereas most of those mixtures were Papaverine based. Verapamil as a calcium channel blocker possess a vasodilator effect, thus it has been tried in very few trials as ICI either alone or in  combination with Papaverine. In another perspective, verapamil was found to have anti-fibrotic properties; therefore it could have a dual benefit besides being a vasodilator. 
Methods: Hereby, our study was conducted trying to assess the effect of ICI of Papaverine/Verapamil mixture on penile erection as well as penile hemodynamics, compared to the traditional Bimix (i.e. Papaverine/Phentolamine) among a subgroup of PDE5I nonresponders (n=50). 
Results: Our results showed that there was statistically significant difference while comparing both mixtures (Papaverine/Phentolamine) vs (Papaverine/Verapamil) concerning IIEF-5, cavernosal artery dilatation, PSV and RI with P-values (0.001, 0.003, 0.006 and 0.003) respectively. 
Conclusion: Therefore, a bi-mixture of (Papaverine/Verapamil) could be a promising combination for treatment of ED via ICI with its dual-effects as cavernosal smooth muscle relaxant causing erection as well as anti-fibrotic properties.
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(2021). A Comparative Pilot Study on The Effect of Intracavernosal Injection Of (Papaverine/Verapamil) And (Papaverine/Phentolamine) In Erectile Dysfunction Patients. European Journal of Molecular & Clinical Medicine, 7(11), 4074-4081.
Mohamed Farid Roaiah, Ahmed Raef Sadek, Ahmed Mohamed Gamal, Mohamed Ahmed Abd El Salam. "A Comparative Pilot Study on The Effect of Intracavernosal Injection Of (Papaverine/Verapamil) And (Papaverine/Phentolamine) In Erectile Dysfunction Patients". European Journal of Molecular & Clinical Medicine, 7, 11, 2021, 4074-4081.
(2021). 'A Comparative Pilot Study on The Effect of Intracavernosal Injection Of (Papaverine/Verapamil) And (Papaverine/Phentolamine) In Erectile Dysfunction Patients', European Journal of Molecular & Clinical Medicine, 7(11), pp. 4074-4081.
A Comparative Pilot Study on The Effect of Intracavernosal Injection Of (Papaverine/Verapamil) And (Papaverine/Phentolamine) In Erectile Dysfunction Patients. European Journal of Molecular & Clinical Medicine, 2021; 7(11): 4074-4081.
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