Hyperuricemia And Carotid Atherosclerosis Or Stenosis In Egyptian Stroke Patients
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 4082-4092
Abstract
Aim Of Study: To Access The Hemodynamic Changes Of Carotid Circulation, Either Atherosclerosis Or Stenosis, And Its Correlation With Uric Acid Level As A Marker Of Atherosclerosis.Methods: This Is A Cross Sectional Observational Study Was Done On 130 Stroke Egyptian Patients Who Attended Al Zahraa University Hospital From Period January 2019 To December 2020. Demographic, Clinical Data And Extracranial And Transcranial Carotid Ultrasound Findings Are Analyzed And Correlated With The Level Of Uric Acid.
Results: There Were 81.5% Of Our Subjects Suffered From Carotid Atherosclerosis. 48 (37.1%) Of Them Developed Plaque 48.7% Of These Plaques Causing Extracranial Significant Stenosis More Than 50%. Of All The Stroke Patients 92 Of Them Has A Good Transtemporal Window And Can Be Investigated Well By Transcranial Duplex. We Found That 37.5 (28.5 %) Subjects Developed Significant Intracranial Anterior Circulation Stenosis More Than 50% In Different Segments Of Detected Arteries. The Highest Percentage Was Found In Aca. The Relationship Between Ua Level And Nihss Was Inversely Correlated (P-Value=0.002) (R=- 0.26). Pearson Correlation Analysis Showing That Statistical Correlation Between The High Level Of Ua And Ica Stenosis In Our Studied Patients(P-Value=0.01) (R =-0.372), And Statistical Correlations Between Hyperuricemia And Aca (P-Value=0.009, 0.03) (R=0.276, 0.231) Stenosis And Transcranial Ica Stenosis (P-Value = 0.001) (R = 0.349).
Conclusion: Hemodynamic Significant Of Atherosclerosis In Extracranial And Transcranial Ica And Its Cerebral Branches Among Egyptian Stroke Patients And Significant Correlation Between Serum Ua Level And Intracranial Stenosis.
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