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  2. Volume 7, Issue 11
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Online ISSN: 2515-8260

Volume7, Issue11

Neural Tube Formation Determinants of PAX3 By Non-Canonical WNT, ROR2 And Its Effect on Neural Crest Specifiers Like SOX10, RET Genes

    Nitish Kumar Singh, Ashish, Abhay Kumar Yadav, Manpreet Kaur, Royana Singh

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 4523-4528

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Abstract

Introduction:Anencephaly occurs due to the complete absence of cranial vault and subsequent disruption of the cerebral cortex with a severely damaged brain. In anencephaly, the forebrain and brain stem are exposed. Forebrain either does not develop or is destroyed, leading to the absence of cerebrum and cerebellum.
Material and method: NTD were taken in the study group. During the autopsy clinical findings, external examination, internal examination and photography were done along with the histopathology of the specimens. Total RNA from NTD patient and control was extracted using acid guanidinium thiocyanate-phenol-chloroform extraction
Result: Demonstrated here the differential expression of specific genes like WNT11, ROR-2, PAX3/PAX7, SOX10, RET associated with development of the neural tube affected and normal adjacent tissues.
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(2021). Neural Tube Formation Determinants of PAX3 By Non-Canonical WNT, ROR2 And Its Effect on Neural Crest Specifiers Like SOX10, RET Genes. European Journal of Molecular & Clinical Medicine, 7(11), 4523-4528.
Nitish Kumar Singh, Ashish, Abhay Kumar Yadav, Manpreet Kaur, Royana Singh. "Neural Tube Formation Determinants of PAX3 By Non-Canonical WNT, ROR2 And Its Effect on Neural Crest Specifiers Like SOX10, RET Genes". European Journal of Molecular & Clinical Medicine, 7, 11, 2021, 4523-4528.
(2021). 'Neural Tube Formation Determinants of PAX3 By Non-Canonical WNT, ROR2 And Its Effect on Neural Crest Specifiers Like SOX10, RET Genes', European Journal of Molecular & Clinical Medicine, 7(11), pp. 4523-4528.
Neural Tube Formation Determinants of PAX3 By Non-Canonical WNT, ROR2 And Its Effect on Neural Crest Specifiers Like SOX10, RET Genes. European Journal of Molecular & Clinical Medicine, 2021; 7(11): 4523-4528.
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