Synthesis, Characterization and Anti-Microbial Activity of Some Hydrazone Derivatives
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 4604-4611
Abstract
A combination of phenyl acidic corrosive (10gm, 0.003mole) in acetone, dimethyl Sulfate (10.45ml, 0.007mole), anhydrous potassium carbonate (2.8gm, 0.02mol) was refluxed on a hot plate for 2 hr with intermittent mixing give methyl 2-phenylacetate(1), Methyl 2-phenylacetate (1.78gm, 0.01mole) in liquor was refluxed with hydrazine hydrate (0.38gm, 0.01mole) for 8 hrs framed 2-phenylacetohydrazide, A combination of subbed benzaldehyde (1.22gm, 0.01mole) and 2-phenyl acetohydrazide (1.5gm, 0.01mole) were broken up in methanol then two drops of conc. HCl were added as impetus and blended at room temperature for 2hr framed N'- (4-hydroxybenzylidene)- 2-phenylacetohydrazide3a,N'- (4-(dimethylamino)benzylidene)- 2-phenylacetohydrazide,N'- (2-nitrobenzylide ne)- 2-phenylacetohydrazide, and N'- (4-chloro benz ylidene)- 2-phenylacetohydrazide.
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