Synthesis, Characterization and Anti-Inflammatory Activity of Novel 1, 5-Disubstituted Indole Derivatives
European Journal of Molecular & Clinical Medicine,
2020, Volume 7, Issue 11, Pages 4622-4635
Abstract
A new series of 1,5-disubstituted indole derivatives such as 5-(acetylamino)-1-[(4-flurophenyl)carbonyl]-1H-indole-3-carboxylic acid, 1-[(4-fluorophenyl)carbonyl]-5-[(phenylcarbonyl)amino]-1H-indole-3-carboxylic acid, 1-(4-flurobenzoyl)-5-(4-ethylbenzamido-1H-indole-3-carboxylic acid, 5-(4-nitrobenzamido)-1-(4-flurobenzoyl)-1H-indole-3-carboxylic acid, 5-(4-bromobenzamido)-1-(4-flurobenzoyl)-1H-indole-3-carboxylic acid were synthesized. All the newly synthesized derivatives of 1,5-disubstituted indole derivatives are characterized by spectroscopically and analytically. All compounds were screened for their anti-inflammatory activity. The pharmacological screening of the synthesized compounds showed anti-inflammatory activity ranging from 12.12 to 65.51 % inhibition. The compound I was found to be ne+arly more potent then indomethacin which is used as standard drug. A compound III has shown less activity then indomethacine. Compounds IV and V shown more potent activity than compound –I, II and Indomethacin.
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