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  2. Volume 7, Issue 11
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Online ISSN: 2515-8260

Volume7, Issue11

Synthesis, Characterization and Anti-Inflammatory Activity of Novel 1, 5-Disubstituted Indole Derivatives

    Deepmala Solanki, Vinod K Nakra, Akhilesh Tiwari, Anil Kumar Gupta, Sanyam Gandhi

European Journal of Molecular & Clinical Medicine, 2020, Volume 7, Issue 11, Pages 4622-4635

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Abstract

A new series of 1,5-disubstituted indole derivatives such as 5-(acetylamino)-1-[(4-flurophenyl)carbonyl]-1H-indole-3-carboxylic acid, 1-[(4-fluorophenyl)carbonyl]-5-[(phenylcarbonyl)amino]-1H-indole-3-carboxylic acid, 1-(4-flurobenzoyl)-5-(4-ethylbenzamido-1H-indole-3-carboxylic acid,  5-(4-nitrobenzamido)-1-(4-flurobenzoyl)-1H-indole-3-carboxylic acid,  5-(4-bromobenzamido)-1-(4-flurobenzoyl)-1H-indole-3-carboxylic acid were synthesized. All the newly synthesized derivatives of 1,5-disubstituted indole derivatives are characterized by spectroscopically and analytically. All compounds were screened for their anti-inflammatory activity. The pharmacological screening of the synthesized compounds showed anti-inflammatory activity ranging from 12.12 to 65.51 % inhibition. The compound I was found to be ne+arly more potent then indomethacin which is used as standard drug. A compound III has shown less activity then indomethacine. Compounds IV and V shown more potent activity than compound –I, II and Indomethacin.
 
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(2021). Synthesis, Characterization and Anti-Inflammatory Activity of Novel 1, 5-Disubstituted Indole Derivatives. European Journal of Molecular & Clinical Medicine, 7(11), 4622-4635.
Deepmala Solanki, Vinod K Nakra, Akhilesh Tiwari, Anil Kumar Gupta, Sanyam Gandhi. "Synthesis, Characterization and Anti-Inflammatory Activity of Novel 1, 5-Disubstituted Indole Derivatives". European Journal of Molecular & Clinical Medicine, 7, 11, 2021, 4622-4635.
(2021). 'Synthesis, Characterization and Anti-Inflammatory Activity of Novel 1, 5-Disubstituted Indole Derivatives', European Journal of Molecular & Clinical Medicine, 7(11), pp. 4622-4635.
Synthesis, Characterization and Anti-Inflammatory Activity of Novel 1, 5-Disubstituted Indole Derivatives. European Journal of Molecular & Clinical Medicine, 2021; 7(11): 4622-4635.
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